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Cinacalcet (hydrochloride)
$35 – $180
Products Details
Product Description
– Cinacalcet hydrochloride (AMG-073 hydrochloride) is an orally active, allosteric agonist of Ca receptor (CaR), used for cardiovascular disease treatment.
Web ID
– HY-70037A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H23ClF3N
Citations
– iScience. 2023 Mar.|Patent. US20230147129A1.|Acta Physiol. 2023 Jan 6;e13926.|Calcif Tissue Int. 2023 Feb 8.|Cell Biol Toxicol. 2022 May 30.|Gen Comp Endocrinol. 2018 Oct 1;267:1-8.|J Agric Food Chem. 2021 Nov 8.|J Biol Chem. 2016 Oct 28;291(44):23126-23135.|J Food Sci. 2018 Sep;83(9):2394-2401.|J Med Chem. 2015 Apr 9;58(7):2958-66. |Oxid Med Cell Longev. 2017;2017:3869561.|Oxid Med Cell Longev. 2021 Jan 12;2021:3010548.
References
– [1]D.A. Bushinsky, et al. Effect of cinacalcet on urine calcium excretion and supersaturation in genetic hypercalciuric stone-forming rats. Kidney Int. 2006 May;69(9):1586-92.|[2]Colloton M, et al. Cinacalcet HCl attenuates parathyroid hyperplasia in a rat model of secondary hyperparathyroidism. Kidney Int. 2005 Feb;67(2):467-76.
CAS Number
– 364782-34-3
Molecular Weight
– 393.87
Compound Purity
– 99.99
SMILES
– FC(F)(C1=CC(CCCN[C@@H](C2=C3C=CC=CC3=CC=C2)C)=CC=C1)F.Cl
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : ≥ 50 mg/mL|H2O : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– CaSR;Endogenous Metabolite
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
