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CHPG (sodium salt)
$110 – $960
Products Details
Product Description
– CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].
Web ID
– HY-101364A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C8H7ClNNaO3
References
– [1]Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO<sub>2</sub>-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.|[2]Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.
CAS Number
– 1303993-73-8
Molecular Weight
– 223.59
Compound Purity
– 99.17
SMILES
– O=C(O[Na])C(N)C1=CC(O)=CC=C1Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|H2O : 6.67 mg/mL (ultrasonic;warming;heat to 80°C)
Target
– Akt;ERK;mGluR;NF-κB
Isoform
– ERK;mGluR5;NF-κB
Pathway
– GPCR/G Protein;MAPK/ERK Pathway;Neuronal Signaling;NF-κB;PI3K/Akt/mTOR;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
