Products Details

Product Description

– Chlorotrianisene-d9 is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood[1][2][3].

Web ID

– HY-B2158S

Shipping

– Room temperature

Molecular Formula

– C23H12D9ClO3

References

– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Ruenitz PC, et al. Estrogenic tamoxifen derivatives: categorization of intrinsic estrogenicity in MCF-7 cells. J Steroid Biochem Mol Biol. 1997 Nov-Dec;63(4-6):203-9.|[3]Lounkine E, et al. Large-scale prediction and testing of drug activity on side-effect targets. Nature. 2012 Jun 10;486(7403):361-7.|[4]Kupfer D, et al. Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12;261(1):59-62.

CAS Number

– 1276197-26-2

Molecular Weight

– 389.92

SMILES

– Cl/C(C1=CC=C(C=C1)OC([2H])([2H])[2H])=C(C2=CC=C(C=C2)OC([2H])([2H])[2H])C3=CC=C(C=C3)OC([2H])([2H])[2H]

Clinical Information

– No Development Reported

Research Area

– Endocrinology; Cardiovascular Disease

Solubility

– 10 mM in DMSO

Target

– COX;Estrogen Receptor/ERR;Isotope-Labeled Compounds

Pathway

– Immunology/Inflammation;Others;Vitamin D Related/Nuclear Receptor

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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