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Chloroquine
$66 – $231
Products Details
Product Description
– Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM)[1][2][3][4].
Web ID
– HY-17589A
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C18H26ClN3
Citations
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References
– [1]Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15;193(12):6135-43.|[2]Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672.|[3]Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626.|[4]Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020;55(4):105932.|[5]Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001;20(3):131-135.
CAS Number
– 54-05-7
Molecular Weight
– 319.87
Compound Purity
– 99.82
SMILES
– CC(NC1=CC=NC2=CC(Cl)=CC=C12)CCCN(CC)CC
Clinical Information
– Launched
Research Area
– Cancer; Infection; Inflammation/Immunology
Solubility
– DMSO : 50 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)
Target
– Antibiotic;Autophagy;HIV;Parasite;SARS-CoV;Toll-like Receptor (TLR)
Isoform
– HIV-1;Plasmodium
Pathway
– Anti-infection;Autophagy;Immunology/Inflammation
Product type
– Reference compound
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