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Chk1-IN-6

Products Details

Product Description

– Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.

Web ID

– HY-139901

Shipping

– Room temperature

Applications

– Cancer-Kinase/protease

Molecular Formula

– C16H18F3N7

References

– [1]Jin T, et al. Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile. J Med Chem. 2021 Oct 28;64(20):15069-15090.

CAS Number

– 2428423-77-0

Molecular Weight

– 365.36

SMILES

– N#CC(C=C1)=NC=C1NC2=NC=C(C(F)(F)F)C(NCCC(C)(C)N)=N2

Clinical Information

– No Development Reported

Research Area

– Cancer

Solubility

– 10 mM in DMSO

Target

– Checkpoint Kinase (Chk)

Isoform

– Chk1

Pathway

– Cell Cycle/DNA Damage

Product type

– Reference compound

Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.

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