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Chitin synthase inhibitor 2
SKU
HY-150583-Get quote
Category Reference compound
Tags Anti-infection, Antibiotic;Fungal, Inflammation/Immunology
Products Details
Product Description
– Chitin synthase inhibitor 2 (compound 2b) is a potent inhibitor of chitin synthase with the IC50 value of 0.09 mM and the Ki value of 0.12 mM. Chitin synthase inhibitor 2 has antimicrobial activities in vitro and shows synergistic or additive effects with fluconazole or polyoxin B[1].
Web ID
– HY-150583
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C20H19N3O3
References
– [1]Li B, Shen Y, Wu H, Wu X, Yuan L, Ji Q. Design, synthesis and biological evaluation of novel 3,4-dihydro-2(1H)-quinolinone derivatives as potential chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2020 Jun 1;195:112278.
CAS Number
– 2416338-24-2
Molecular Weight
– 349.38
SMILES
– O=C(NC1C(NC2=C(C=CC=C2)C1)=O)/C=C/C(NC3=CC=CC(C)=C3)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Antibiotic;Fungal
Pathway
– Anti-infection
Product type
– Reference compound
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