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Chelerythrine (chloride)
$79 – $726
Products Details
Product Description
– Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.
Web ID
– HY-12048
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H18ClNO4
Citations
– Harvard Medical School LINCS LIBRARY|J Headache Pain. 2022 Mar 8;23(1):35.|Phytother Res. 2023 Jul 4.|Research Square Preprint. 2020 Oct.|Sci Rep. 2017 Aug 23;7(1):9201.|Cancer Cell Int. 2023 Jun 17;23(1):117.|Cell Commun Signal. 2021 Oct 11;19(1):103.|FASEB J. 2019 Dec;33(12):13644-13659.|Fishes. 2022, 7(5), 229.|Front Pharmacol. 13 May 2021.|Front Physiol. 2021 Oct 28;12:770430.
References
– [1]Chan SL, et al.Identification of chelerythrine as an inhibitor of BclXL function.J Biol Chem. 2003 Jun 6;278(23):20453-6.|[2]Tang ZH, et al.Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells.Redox Biol. 2017 Aug;12:367-376.|[3]Li W, et al. Effect of Chelerythrine Against Endotoxic Shock in Mice and Its Modulation of Inflammatory Mediators in Peritoneal Macrophages Through the Modulation of Mitogen-Activated Protein Kinase (MAPK) Pathway. Inflammation. 2012 Jul 24.|[4]Pencikova K, et al. Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19(10):890-5. Epub 2012 May 14.|[5]Chen XM, et al. Chelerythrine chloride induces apoptosis in renal cancer HEK-293 and SW-839 cell lines. Oncol Lett. 2016 Jun;11(6):3917-3924|[6]Herbert JM, et al. Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 1990 Nov 15;172(3):993-9.
CAS Number
– 3895-92-9
Molecular Weight
– 383.82
Compound Purity
– 99.42
SMILES
– C[N+]1=CC2=C(C(OC)=CC=C2C3=C1C4=CC5=C(OCO5)C=C4C=C3)OC.[Cl-]
Clinical Information
– No Development Reported
Research Area
– Cancer; Metabolic Disease; Inflammation/Immunology
Solubility
– DMSO : 4.35 mg/mL (ultrasonic)
Target
– Apoptosis;Autophagy;Bcl-2 Family;PKC
Isoform
– PKC
Pathway
– Apoptosis;Autophagy;Epigenetics;TGF-beta/Smad
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
