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CGS 21680 (Hydrochloride)
$97 – $835
Products Details
Product Description
– CGS 21680 Hydrochloride is a selective adenosine A2A receptor agonist with a Ki of 27 nM.
Web ID
– HY-13201A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C23H30ClN7O6
Citations
– Research Square Print. December 13th, 2022.|Cell Death Dis. 2020 Mar 23;11(3):202.|Ecotoxicol Environ Saf. 2022 Dec 12;249:114410.|Iran J Basic Med Sci. 10, Oct 2021.|J Neuroinflammation. 2022 Feb 18;19(1):52.|Neurochem Int. 2021 Feb 9;145:104983.|Research Square Preprint. 2021 Aug.
References
– [1]Bao R, et al. Adenosine and the adenosine A2A receptor agonist, CGS21680, upregulate CD39 and CD73 expression through E2F-1 and CREB in regulatory T cells isolated from septic mice. Int J Mol Med. 2016 Sep;38(3):969-75.|[2]Zhang M, et al. Activation of the adenosine A2A receptor exacerbates experimental autoimmune neuritis in Lewis rats in association with enhanced humoral immunity. J Neuroimmunol. 2016 Apr 15;293:129-36.|[3]Melani A, et al. Low doses of the selective adenosine A2A receptor agonist CGS21680 are protective in a rat model of transient cerebral ischemia. Brain Res. 2014 Mar 10;1551:59-72.|[4]Rosaria Volpini, et al. Adenosine receptor agonists: synthesis and binding affinity of 2-(aryl)alkylthioadenosine derivatives.|[5]Komaki S, et al. Trk and cAMP-dependent survival activity of adenosine A(2A) agonist CGS21680 on rat motoneurons in culture. Neurosci Lett. 2012 Jul 26;522(1):21-4.
CAS Number
– 124431-80-7
Molecular Weight
– 535.98
Compound Purity
– 99.70
SMILES
– O=C(O)CCC1=CC=C(CCNC2=NC3=C(N=CN3[C@H]4[C@H](O)[C@H](O)[C@@H](C(NCC)=O)O4)C(N)=N2)C=C1.Cl
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– DMSO : ≥ 20 mg/mL|H2O : 1 mg/mL (ultrasonic;adjust pH to 1 with HCl)
Target
– Adenosine Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
