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Products Details
Product Description
– cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1].
Web ID
– HY-149526
Shipping
– Room temperature
Molecular Formula
– C18H19NO8
References
– [1]Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. .
CAS Number
– 858770-07-7
Molecular Weight
– 377.35
SMILES
– COC1=CC2=C(C(C)=C(CCC(N(CC(O)=O)CC(O)=O)=O)C(O2)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Cyclic GMP-AMP Synthase
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
