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cGAMP
$330 – $1,850
Products Details
Product Description
– cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4].
Web ID
– HY-12512
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C20H24N10O13P2
Citations
– Biochem Pharmacol. 2023 May 19;213:115618.|Biomaterials. 2023 Mar 31, 122104.|Cell Rep. 2023 Apr 5;42(4):112328.|Chem Eng J. 2022: 140190.|J Nanobiotechnology. 2022 Jan 6;20(1):23.|bioRxiv. 2020 Jul.|Patent. US20210017607A1.
References
– [1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA.
Science. 2013 Feb 15;339(6121):826-30.|[2]Skrnjug I, et al. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS One. 2014 Oct 8;9(10):e110150.|[3]Liu Y, et al. Activated STING in a vascular and pulmonary syndrome. N Engl J Med. 2014 Aug 7;371(6):507-18.|[4]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.
CAS Number
– 849214-04-6
Molecular Weight
– 674.41
Compound Purity
– 99.22
SMILES
– O=P(O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1COP4(O)=O)(O)OC[C@@H]5[C@@H](O4)[C@@H](O)[C@H](N6C=NC7=C6N=C(N)NC7=O)O5
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– H2O : 180 mg/mL (ultrasonic)
Target
– STING
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
