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Products Details
Product Description
– CFTR activator 1 is a potent and selective CFTR activator, with an EC50 of 23 nM. CFTR activator 1 can be used to ameliorate dry eye disease[1].
Web ID
– HY-152264
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H27N5O4
References
– [1]Kim BY, et, al. Synthetic Strategies for Improving Solubility: Optimization of Novel Pyrazolo[1,5- a]pyrimidine CFTR Activator That Ameliorates Dry Eye Disease. J Med Chem. 2023 Jan 12;66(1):413-434.
CAS Number
– 2768261-09-0
Molecular Weight
– 485.53
SMILES
– O=C(N1C[C@@H](N(CC1)C(C2=CC=CC=C2)=O)C)C3=NN4C(C5=CC(OC)=C(C=C5)OC)=CC=NC4=C3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– CFTR
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
