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CF53
$450 – $3,350
Products Details
Product Description
– CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of <1 nM, Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo[1].
Web ID
– HY-112610
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H25N7O2
References
– [1]Zhao Y, et al. Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor. J Med Chem. 2018 Jul 26;61(14):6110-6120.
CAS Number
– 1808160-52-2
Molecular Weight
– 443.50
Compound Purity
– 99.78
SMILES
– COC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(NC5=CC(C6CC6)=NN5C)=NC(C)=N3)C4=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 110 mg/mL (ultrasonic)
Target
– Epigenetic Reader Domain;Histone Acetyltransferase
Isoform
– BRD2;BRD3;BRD4;BRDT;CBP/p300;CECR2;TIP60
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
