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Product Description
– Cetirizine Impurity B dihydrochloride is an impurity of Cetirizine dihydrochloride. Cetirizine, a second-generation antihistamine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response[1][2][3].
Web ID
– HY-100660A
Shipping
– Room temperature
Molecular Formula
– C19H23Cl3N2O2
References
– [1]Caroline M. Spencer, et al. Cetirizine. Drugs 46 (6): 1055-1080, 1993.|[2]Shih MY, et al. Influence of cetirizine and levocetirizine on two cytokines secretion in human airway epithelial cells. Allergy Asthma Proc. 2008 Sep-Oct;29(5):480-5.|[3]Shimizu T, et al. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004 Jan;34(1):103-9.
CAS Number
– 1000690-91-4
Molecular Weight
– 417.76
SMILES
– O=C(O)CN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1.[H]Cl.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 250 mg/mL (ultrasonic)
Target
– Drug Metabolite
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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