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Products Details
Product Description
– Cerivastatin is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin reduces low-density lipoprotein cholesterol levels. Cerivastatin also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect[1][2][3].
Web ID
– HY-129458
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H34FNO5
References
– [1]Denoyelle C, et al. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. Carcinogenesis. 2001 Aug;22(8):1139-48.|[2]Stein E, et al. Cerivastatin, a New Potent Synthetic HMG Co-A Reductase Inhibitor: Effect of 0.2 mg Daily in Subjects With Primary Hypercholesterolemia. J Cardiovasc Pharmacol Ther. 1997 Jan;2(1):7-16.|[3]Furberg CD, et al. Withdrawal of cerivastatin from the world market. Curr Control Trials Cardiovasc Med. 2001;2(5):205-207.
CAS Number
– 145599-86-6
Molecular Weight
– 459.55
SMILES
– O=C(O)C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C(COC)=C(C(C)C)N=C1C(C)C
Clinical Information
– Launched
Research Area
– Cancer; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Ferroptosis;HMG-CoA Reductase (HMGCR)
Pathway
– Apoptosis;Metabolic Enzyme/Protease
Product type
– Reference compound
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