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Ceranib-2
SKU
HY-116147-10 mg
Category Reference compound
Tags Apoptosis;GPCR/G Protein, Apoptosis;LPL Receptor, Cancer
$60 – $620
Products Details
Product Description
– Ceranib-2 is a potent and nonlipid ceramidase inhibitor that inhibits cellular ceramidase activity with an IC50 of 28 μM in SKOV3 cells. Ceranib-2 induces the accumulation of multiple ceramide species, decreases levels of sphingosine and sphingosine-1-phosphate (S1P), and induces cell apoptosis. Anticancer activity[1][2].
Web ID
– HY-116147
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H19NO3
References
– [1] Draper JM, et al. Discovery and evaluation of inhibitors of human ceramidase. Mol Cancer Ther. 2011 Nov;10(11):2052-61.|[2]Kus G, et al. Induction of apoptosis in prostate cancer cells by the novel ceramidase inhibitor ceranib-2. In Vitro Cell Dev Biol Anim. 2015 Nov;51(10):1056-63.
CAS Number
– 1402830-75-4
Molecular Weight
– 381.42
Compound Purity
– 99.25
SMILES
– O=C1NC(C=CC=C2)=C2C(C3=CC=CC=C3)=C1C(/C=C/C4=CC=C(C=C4)OC)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– Apoptosis;LPL Receptor
Pathway
– Apoptosis;GPCR/G Protein
Product type
– Reference compound
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