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Products Details
Product Description
– CEP-9722, the proagent of CEP-8983, is a selective and orally active PARP-1 and PARP-2 inhibitor with IC50s of 20 nM and 6 nM, respectively. CEP-9722 has anticancer effects[1][2].
Web ID
– HY-105303
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C24H26N4O3
References
– [1]Weiguo Jian, et al. Activity of CEP-9722, a poly (ADP-ribose) polymerase inhibitor, in urothelial carcinoma correlates inversely with homologous recombination repair response to DNA damage. Anticancer Drugs. 2014 Sep;25(8):878-86.|[2]Ruth Plummer, et al. Phase 1 dose-escalation study of the PARP inhibitor CEP-9722 as monotherapy or in combination with temozolomide in patients with solid tumors. Cancer Chemother Pharmacol. 2014 Aug;74(2):257-65.
CAS Number
– 916574-83-9
Molecular Weight
– 418.49
SMILES
– O=C(N1CN2CCN(C)CC2)C3=C4C5=C(OC)C=CC=C5NC4=C6C(CCC6)=C3C1=O
Clinical Information
– Phase 2
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– PARP
Isoform
– PARP1;PARP2
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
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