Download Files:
Products Details
Product Description
– CEM114 is an effective chemical epigenetic modifier (CEM) that recruits endogenous chromatin machinery through CRISPR-Cas9 systems[1].
Web ID
– HY-136572
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C84H122FN9O19S
References
– [1]Anna M Chiarella, et al. Dose-dependent activation of gene expression is achieved using CRISPR and small molecules that recruit endogenous chromatin machinery. Nat Biotechnol. 2020 Jan;38(1):50-55.
CAS Number
– 2279062-54-1
Molecular Weight
– 1612.98
SMILES
– CC1=NOC(C)=C1C2=CC=C(C3=C2)N(C(CCC(C=C4)=CC(F)=C4OCC(N=N5)=CN5CCOCCOCCOCCNC(CCSCCC[C@H](/C=C(C[C@@H](C[C@@H]([C@](O[C@]6(C7=O)O)([H])[C@H](C[C@H]6C)OC)OC)C)C)C(C[C@@H]([C@H]([C@H](OC([C@@](CCCC8)([H])N8C7=O)=O)/C(C)=C/[C@H](CC[C@H]9O)C[C@H]9OC)C)O)=O)=O)=N3)CCN%10CCOCC%10
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CRISPR/Cas9;Epigenetic Reader Domain
Pathway
– Cell Cycle/DNA Damage;Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
