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Product Description
– CDN-A is a cyclic di-nucleotide, it can be used to synthesis antibody-drug conjugate (ADC). Cyclic di-nucleotides are potent stimulators of innate and adaptive immune responses. In humans, cyclic di-nucleotide, which are either produced endogenously in response to foreign DNA or by invading bacterial pathogens, trigger the innate immune system by activating the expression of interferon genes[1][2][3].
Web ID
– HY-148420
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H29N11O12P2
References
– [1]Chen, Zhijian, et al. Antinbody-sting agonist conjugates and their use in immunotherapy. US 2021/0015941 Al. 2021.|[2]Lirussi D, et al. Type I IFN and not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway. EBioMedicine. 2017 Aug;22:100-111.|[3]Schaap P. Cyclic di-nucleotide signaling enters the eukaryote domain. IUBMB Life. 2013 Nov;65(11):897-903.
CAS Number
– 2586047-09-6
Molecular Weight
– 701.48
SMILES
– O=P(O)(O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC=N3)O[C@@H]1COP4(O)=O)OC[C@@H](O5)[C@@H](CCN)[C@@H](O4)[C@@H]5N6C=NC7=C6N=C(N)NC7=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– STING
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
