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Products Details
Product Description
– CDK8-IN-7 (compound 12) is a potent and selective cyclin-dependent kinase 8 (CDK8) inhibitor with an Kd of 3.5 nM. CDK8-IN-7 shows cytotoxicity for MOLM-13, OCI-AML3, MV4-11, NRK and H9c2 cells with IC50s of 5.9, 4.8, 5.4, 16.2, 12.5-25 µM, respectively. CDK8-IN-7 has the potential for the research of AML-cancer[1].
Web ID
– HY-147717
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C30H40N2
References
– [1]Solum E, et al. New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation. Bioorg Med Chem. 2020 May 15;28(10):115461.
CAS Number
– 2415156-30-6
Molecular Weight
– 428.65
SMILES
– C[C@@]12C(C3=CC=CC4=C3C=CN=C4)=CC[C@@]1([H])[C@]5([H])CC[C@@]6([H])C[C@H](N(C)C)CC[C@]6(C)[C@@]5([H])CC2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK
Isoform
– CDK8
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
