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Products Details
Product Description
– CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines[1].
Web ID
– HY-147646
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H12ClN3O2S2
References
– [1]Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):115633.
CAS Number
– 2459916-56-2
Molecular Weight
– 353.85
SMILES
– COC1=CC=C(C(OC)=C1)N2C(SC3=C2N=C(N=C3Cl)C)=S
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;CDK
Isoform
– CDK1
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
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