Download Files:
Products Details
Product Description
– CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
Web ID
– HY-146253
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C15H16N2O2S
References
– [1]Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761.
CAS Number
– 2414633-49-9
Molecular Weight
– 288.36
SMILES
– O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;Caspase;CDK
Isoform
– Bax;Bcl-2;Caspase 3;CDK1;CDK2;CDK4
Pathway
– Apoptosis;Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
