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Products Details
Product Description
– CD38 inhibitor 3 (compound 1) is a potent CD38 inhibitor (IC50=11 nM). CD38 inhibitor 3 can promote mitochondrial biogenesis, reduce lactate levels, and increase NAD+ content and Nrf2 expression. In a model of mitochondrial myopathy, CD38 inhibitor 3 increases muscle contraction/development and improves exercise tolerance in Pus1-/- mice[1].
Web ID
– HY-156120
Shipping
– Room temperature
Molecular Formula
– C16H14F3N7O3
References
– [1]Li Y, et al. Discovery of a First-in-Class CD38 Inhibitor for the Treatment of Mitochondrial Myopathy. J Med Chem. 2023 Sep 11.. .
CAS Number
– 2857868-82-5
Molecular Weight
– 409.32
SMILES
– O=C(C1=NC(N2C=NC=C2)=NC(C(F)(F)F)=C1)NC3=CN=C(OCCOC)N=C3
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– CD38
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
