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CCT241533 (hydrochloride)
$198 – $1,624
Products Details
Product Description
– CCT241533 hydrochloride is a potent and selective CHK2 inhibitor with an IC50 of 3 nM and a Ki of 1.16 nM[1].
Web ID
– HY-14715B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H28ClFN4O4
Citations
– J Cell Biol. 2021 Feb 1;220(2):e201911025.|Cell Death Differ. 2021 Jul;28(7):2060-2082.|Int J Mol Sci. 2022, 23(20), 12290.|J Chem Inf Model. 2017 Nov 27;57(11):2699-2706.
References
– [1]Caldwell JJ, et al. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90.|[2]Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72.
CAS Number
– 1431697-96-9
Molecular Weight
– 478.9442232
Compound Purity
– 99.87
SMILES
– [H]Cl.COC1=C(OC)C=C(C(N[C@H]2[C@H](C(C)(C)O)CNC2)=NC(C3=C(O)C=CC(F)=C3)=N4)C4=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 33.33 mg/mL (ultrasonic)
Target
– Checkpoint Kinase (Chk)
Isoform
– Chk1;Chk2
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
