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Products Details
Product Description
– CCT241533 is a potent and selective ATP competitive inhibitor of CHK2 with an IC50 of 3 nM and Ki of 1.16 nM[1].
Web ID
– HY-14715
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C23H27FN4O4
Citations
– Cell Death Differ. 2021 Jul;28(7):2060-2082.|Int J Mol Sci. 2022, 23(20), 12290.|J Chem Inf Model. 2017 Nov 27;57(11):2699-2706. |J Cell Biol. 2021 Feb 1;220(2):e201911025.
References
– [1]Anderson VE, et al. CCT241533 is a potent and selective inhibitor of CHK2 that potentiates the cytotoxicity of PARP inhibitors. Cancer Res. 2011 Jan 15;71(2):463-72.|[2]Caldwell JJ, et al. Structure-based design of potent and selective 2-(quinazolin-2-yl)phenol inhibitors of checkpoint kinase 2. J Med Chem. 2011 Jan 27;54(2):580-90.
CAS Number
– 1262849-73-9
Molecular Weight
– 442.48
SMILES
– COC1=C(OC)C=C(C(N[C@H]2[C@H](C(C)(C)O)CNC2)=NC(C3=C(O)C=CC(F)=C3)=N4)C4=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Checkpoint Kinase (Chk)
Isoform
– Chk1;Chk2
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
