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Products Details
Product Description
– CCG-273463 is a potent, selective and covalent GRK5 inhibitor with an IC50 value of 8.6 nM. CCG-273463 can be used in the research of heart failure, hypertrophic cardiomyopathy, and cancer[1].
Web ID
– HY-150040
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H25BrN4O3
References
– [1]Rachel A Rowlands, et al. Generation of Highly Selective, Potent, and Covalent G Protein-Coupled Receptor Kinase 5 Inhibitors. J Med Chem. 2021 Jan 14;64(1):566-585.
CAS Number
– 2750413-99-9
Molecular Weight
– 521.41
SMILES
– O=C1NC2=CC=C(C=C2/C1=C/C3=C(C(NC(CBr)=O)=C(N3)C)C)C(N[C@H](C)C4=CC=CC=C4)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– G Protein-coupled Receptor Kinase (GRK)
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
