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Products Details
Product Description
– CC-401 is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.
Web ID
– HY-13022A
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C22H24N6O
Citations
– Cell Syst. 2018 Apr 25;6(4):424-443.e7.|J Med Chem. 2023 Mar 6.|Mol Cancer Res. 2016 Aug;14(8):753-63.|Harvard Medical School LINCS LIBRARY|Science. 2017 Dec 1;358(6367):eaan4368.
References
– [1]Ma FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89(4):470-84.|[2]Ma FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18(2):472-84.|[3]Vasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.
CAS Number
– 395104-30-0
Molecular Weight
– 388.47
SMILES
– C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C=C4)C5=NC=NN5
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– JNK
Isoform
– JNK
Pathway
– MAPK/ERK Pathway
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
