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CC-115
$99 – $572
Products Details
Product Description
– CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.
Web ID
– HY-16962
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C16H16N8O
Citations
– Front Pharmacol. 2020 Nov 11;11:580407.|Front Pharmacol. 2020 Nov 11;11:580407.
References
– [1]Mortensen DS, et al. Optimization of a Series of Triazole Containing Mammalian Target of Rapamycin (mTOR) Kinase Inhibitors and the Discovery of CC-115. J Med Chem. 2015 Jul 23;58(14):5599-5608.
CAS Number
– 1228013-15-7
Molecular Weight
– 336.35
Compound Purity
– 98.04
SMILES
– O=C1CN=C2C(N1CC)=NC(C3=C(C)N=C(C4=NN=CN4)C=C3)=CN2
Clinical Information
– Phase 1
Research Area
– Cancer
Solubility
– DMSO : 20 mg/mL (ultrasonic)
Target
– DNA-PK;mTOR
Isoform
– mTOR;mTORC1;mTORC2
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
