Download Files:
Products Details
Product Description
– CBP/p300-IN-19 is a potent p300/CBP HAT inhibitor with IC50s of 1.4, 2.2, >100, >100 µM for p300-HAT, CBP-HAT, PCAF, Myst3, respectively. CBP/p300-IN-19 shows antitumor activity[1].
Web ID
– HY-146277
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C30H27N3O3
References
– [1]Nie S, et al. Structure-activity relationship and antitumor activity of 1,4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP. Eur J Med Chem. 2022 Jul 5;237:114407.
CAS Number
– 2592638-13-4
Molecular Weight
– 477.55
SMILES
– C1(C2=CC=C(C3=COC=C3)C=C2)=NC=C(OCC4CCNCC4)N=C1C5=CC=C(C6=COC=C6)C=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Acetyltransferase
Isoform
– CBP/p300;GCN5/PCAF
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
