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Products Details
Product Description
– CBP/p300-IN-18 (compound 8) is a potent EP300/CBP HAT inhibitor with IC50s of 0.056, 0.46 µM for HAT EP300 and LK2 H3K27, respectively[1].
Web ID
– HY-143442
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C25H27FN4O3
References
– [1]Kanada R, et al. Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring. Bioorg Med Chem Lett. 2022 Jun 15;66:128726.
Molecular Weight
– 450.51
SMILES
– O=C([C@@H]1N(C(C2(C3=CC=C(OC)C=C3)CCCC2)=O)C[C@H](F)C1)NC4=CC=CC5=C4C=NN5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Histone Acetyltransferase
Isoform
– CBP/p300
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
