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Products Details
Product Description
– CBP/p300-IN-15 (compound 13a) is a potent p300/CBP inhibitor, with IC50 values of 2.50 and 28.0 nM, respectively. CBP/p300-IN-15 shows good activity against OVCAR-3 and A2780 cell line, with EC50 values of 0.865 and 2.71 μM, respectively. CBP/p300-IN-15 can be used for ovarian cancer research[1].
Web ID
– HY-143339
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H28N4O5
References
– [1]Ding H, et al. Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer. Bioorg Med Chem. 2021 Dec 15;52:116512.
CAS Number
– 2379409-91-1
Molecular Weight
– 476.52
SMILES
– CNC(NC1=CC=C2C(CC[C@@]23OC(N(C3=O)CC(N4CC5=CC=CC=C5CC[C@H]4C)=O)=O)=C1)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain;Histone Acetyltransferase
Isoform
– CBP/p300
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
