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Products Details
Product Description
– Cbl-b-IN-15 (compound 25) is an inhibitor of the RING finger E3 ligase Cbl (IC50: 15 nM). Cbl-b refers to Casitas B-lineage lymphoma proto-oncogene-b, which inhibits T-cell, natural killer (NK) cell, and B-cell activation. Cbl-b-IN-15 activates T cell function with EC50=0.41 μM[1].
Web ID
– HY-155477
Shipping
– Room temperature
Molecular Formula
– C27H27N5O3
References
– [1]Boerth J A et al. Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity[J]. ACS Medicinal Chemistry Letters, 2023.
Molecular Weight
– 469.53
SMILES
– O=C1[C@@H](NC(C2=CC=CC=C2CN3CCO[C@@H](C)C3)=O)N=C(C4=CC=CC=C4)C5=CC=NC=C5N1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– E1/E2/E3 Enzyme
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
