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CAY10505
$32 – $230
Products Details
Product Description
– CAY10505 is a potent and selective PI3Kγ inhibitor with an IC50 of 30 nM in neurons.
Web ID
– HY-13530
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H8FNO3S
References
– [1]Jingyi Wang, et al. MiR-1976 Knockdown Promotes Epithelial-Mesenchymal Transition and Cancer Stem Cell Properties Inducing Triple-Negative Breast Cancer Metastasis. Cell Death Dis. 2020 Jul 3;11(7):500.|[2]Sun YY, Lin SH et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. 2013 Jul 19;8(7):e69019.|[3]Hofmann C, et al. PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform. Br J Haematol. 2014 Aug;166(4):529-39.|[4]Tyagi S. Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats. Can J Physiol Pharmacol. 2012 Jul, 90(7), 881-5.
CAS Number
– 1218777-13-9
Molecular Weight
– 289.28
Compound Purity
– 99.75
SMILES
– O=C(NC/1=O)SC1=CC2=CC=C(C3=CC=C(F)C=C3)O2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : ≥ 34 mg/mL
Target
– Apoptosis;PI3K
Isoform
– PI3Kγ
Pathway
– Apoptosis;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
