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CAY10404

SKU HY-121537-10 mg Category Reference compound Tags Akt;Apoptosis;COX, Apoptosis;Immunology/Inflammation;PI3K/Akt/mTOR, Cancer; Inflammation/Immunology; Neurological Disease

USD90 – USD850

Size

5 mg 10mM/1mL 10 mg 25 mg 50 mg 100 mg

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Products Details

Product Description

– CAY10404 is a potent and selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 1 nM and a selectivity index (SI; COX-1 IC50/COX-2 IC50) of >500000. CAY10404 is a potent PKB/Akt and MAPK signaling pathways inhibitor and induces apoptosis in non-small cell lung cancer (NSCLC) cells. CAY10404, a diarylisoxazole, has good analgesic, anti-inflammatory, and anti-cancer activities[1][2][3].

Web ID

– HY-121537

Storage Temperature

– -20°C (Powder, stored under nitrogen)

Shipping

– Blue Ice

Applications

– COVID-19-immunoregulation

Molecular Formula

– C17H12F3NO3S

References

– [1]Yongseon Cho, et al. Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. Respirology. 2009 Aug;14(6):850-8.|[2]A G Habeeb, et al. Design and synthesis of 4,5-diphenyl-4-isoxazolines: novel inhibitors of cyclooxygenase-2 with analgesic and antiinflammatory activity. J Med Chem. 2001 Aug 30;44(18):2921-7.|[3]Joshua A Robertson, et al. The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury. Am J Respir Cell Mol Biol. 2012 Sep;47(3):387-94.

CAS Number

– 340267-36-9

Molecular Weight

– 367.34

Compound Purity

– 99.79

SMILES

– FC(C1=C(C2=CC=CC=C2)C(C3=CC=C(S(=O)(C)=O)C=C3)=NO1)(F)F

Clinical Information

– No Development Reported

Research Area

– Cancer; Inflammation/Immunology; Neurological Disease

Solubility

– DMSO : 100 mg/mL (ultrasonic)

Target

– Akt;Apoptosis;COX

Isoform

– COX-1;COX-2

Pathway

– Apoptosis;Immunology/Inflammation;PI3K/Akt/mTOR

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.