Products Details

Product Description

– Carvedilol-d5 is deuterium labeled Carvedilol. Carvedilol (BM 14190) is a non-selective β/α-1 blocker[1]. Carvedilol inhibits lipid peroxidation in a dose-dependent manner with an IC50 of 5 μM. Carvedilol is a multiple action antihypertensive agent with potential use in angina and congestive heart failure[2]. Carvedilol is an autophagy inducer that inhibits the NLRP3 inflammasome[3].

Web ID

– HY-B0006S2

Shipping

– Room temperature

Applications

– COVID-19-immunoregulation

Molecular Formula

– C24H21D5N2O4

References

– [1]Eggertsen R, et al. Acute haemodynamic effects of carvedilol (BM 14190), a new combined beta-adrenoceptor blocker and precapillary vasodilating agent, in hypertensive patients. Eur J Clin Pharmacol. 1984;27(1):19-22.|[2]Feuerstein GZ, et al. Myocardial protection by the novel vasodilating beta-blocker, carvedilol: potential relevance of anti-oxidant activity. J Hypertens Suppl. 1993 Jun;11(4):S41-8.|[3]Wong WT, et al. Repositioning of the β-Blocker Carvedilol as a Novel Autophagy Inducer That Inhibits the NLRP3 Inflammasome. Front Immunol. 2018 Aug 22;9:1920.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number

– 929106-58-1

Molecular Weight

– 411.51

SMILES

– COC(C=CC=C1)=C1OCCNC([2H])([2H])C(O)([2H])C([2H])([2H])OC2=C3C4=CC=CC=C4NC3=CC=C2

Clinical Information

– No Development Reported

Research Area

– Cancer; Inflammation/Immunology; Cardiovascular Disease

Solubility

– 10 mM in DMSO

Target

– Adrenergic Receptor;Autophagy;Isotope-Labeled Compounds

Pathway

– Autophagy;GPCR/G Protein;Neuronal Signaling;Others

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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