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Cariporide
$50 – $440
Products Details
Product Description
– Cariporide (HOE-642) is a selective Na+/H+ exchange inhibitor.
Web ID
– HY-19693
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C12H17N3O3S
References
– [1]Teshima Y, et al. Cariporide (HOE642), a selective Na+-H+ exchange inhibitor, inhibits the mitochondrial death pathway. Circulation. 2003 Nov 4;108(18):2275-81.|[2]Chang HB, et al. Na(+)/H(+) exchanger in the regulation of platelet activation and paradoxical effects of cariporide. Exp Neurol. 2015 Oct;272:11-6.|[3]O’Donnell ME, et al. Intravenous HOE-642 reduces brain edema and Na uptake in the rat permanent middle cerebral artery occlusion model of stroke: evidence for participation of the blood-brain barrier Na/H exchanger. J Cereb Blood Flow Metab. 2013 Feb;33(2):225-34.
CAS Number
– 159138-80-4
Molecular Weight
– 283.35
Compound Purity
– 99.89
SMILES
– O=C(NC(N)=N)C1=CC=C(C(C)C)C(S(=O)(C)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Cardiovascular Disease; Cancer
Solubility
– DMSO : ≥ 100 mg/mL
Target
– Na+/H+ Exchanger (NHE)
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
