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Carbenoxolone (disodium)
$80 – $200
Products Details
Product Description
– Carbenoxolone disodium is the active metabolite of Glycyrrhizic acid (HY-N0184) and the inhibitor of human 11β-HSD and bacterial 3α, 20β-HSD[1]. Carbenoxolone disodium is an uncoupling agent for gap junctions and a potent inhibitor of Vaccinia virus replication[2]. Carbenoxolone disodium is used for the study of peptic, esophageal and oral ulceration and inflammation. Carbenoxolone disodium inhibits Vaccinia virus replication.
Web ID
– HY-B1367
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-anti-virus
Molecular Formula
– C34H48Na2O7
References
– [1]W L Duax, et al. Steroid Dehydrogenase Structures, Mechanism of Action, and Disease. Vitam Horm. 2000;58:121-48.|[2]Hossein Hosseinzadeh, et al. Anticonvulsant, Sedative and Muscle Relaxant Effects of Carbenoxolone in Mice. BMC Pharmacol. 2003 Apr 29;3:3.|[3]Ismar R Haga, et al. Carbenoxolone-mediated Cytotoxicity Inhibits Vaccinia Virus Replication in a Human Keratinocyte Cell Line. Sci Rep. 2018 Nov 16;8(1):16956.|[4]Ismar R Haga, et al. Carbenoxolone-mediated cytotoxicity inhibits Vaccinia virus replication in a human keratinocyte cell line. Sci Rep. 2018 Nov 16;8(1):16956.
CAS Number
– 7421-40-1
Molecular Weight
– 614.72
Compound Purity
– 99.88
SMILES
– CC(C)([C@]1([H])CC[C@@]([C@@]2(CC[C@]3(CC[C@](C[C@@]3([H])C2=C4)(C)C(O[Na])=O)C)C)5C)[C@@H](OC(CCC(O[Na])=O)=O)CC[C@]1(C)[C@@]5([H])C4=O
Clinical Information
– Launched
Research Area
– Infection; Inflammation/Immunology
Solubility
– DMSO : 16.67 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Target
– 11β-HSD;Gap Junction Protein;Orthopoxvirus
Pathway
– Anti-infection;Cytoskeleton;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
