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Products Details
Product Description
– Cannflavin A can be isolated from Cannabis sativa L. Cannflavin A has anti-cancer, neuroprotective and anti-inflammatory activity. Cannflavin A inhibits Aβ1-42 aggregation. Cannflavin A also inhibits kynurenine-3-monooxygenase (KMO). Cannflavin A activates apoptosis via caspase-3 cleavage[1][2][3][4].
Web ID
– HY-W748591
Shipping
– Room temperature
Applications
– Neuroscience-Neurodegeneration
Molecular Formula
– C26H28O6
References
– [1]Rea KA, et al. Biosynthesis of cannflavins A and B from Cannabis sativa L. Phytochemistry. 2019 Aug;164:162-171.|[2]Eggers C, et al. Novel cannabis flavonoid, cannflavin A displays both a hormetic and neuroprotective profile against amyloid β-mediated neurotoxicity in PC12 cells: Comparison with geranylated flavonoids, mimulone and diplacone. Biochem Pharmacol. 2019 Nov;169:113609.|[3]Tomko AM, et al. Anti-cancer properties of cannflavin A and potential synergistic effects with gemcitabine, cisplatin, and cannabinoids in bladder cancer. J Cannabis Res. 2022 Jul 22;4(1):41.|[4]Puopolo T, et al. Gram-Scale Preparation of Cannflavin A from Hemp (Cannabis sativa L.) and Its Inhibitory Effect on Tryptophan Catabolism Enzyme Kynurenine-3-Monooxygenase. Biology (Basel). 2022 Sep 28;11(10):1416.
CAS Number
– 76735-57-4
Molecular Weight
– 436.50
SMILES
– OC1=C2C(OC(C3=CC(OC)=C(C=C3)O)=CC2=O)=CC(O)=C1C/C=C(C)/CC/C=C(C)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Amyloid-β, Apoptosis
Pathway
– Apoptosis, Neuronal Signaling
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
