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Products Details
Product Description
– Canagliflozin-d6 is the deuterium labeled Canagliflozin[1]. Canagliflozin (JNJ 28431754) is a selective SGLT2 inhibitor with IC50s of 2 nM, 3.7 nM, and 4.4 nM for mSGLT2, rSGLT2, and hSGLT2 in CHOK cells, respectively[2].
Web ID
– HY-10451S2
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C24H19D6FO5S
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Liang Y, et al.
Effect of canagliflozin on renal threshold for glucose, glycemia, and body weight in normal and diabetic animal models.
PLoS One. 2012;7(2):e30555.
Molecular Weight
– 450.55
SMILES
– O[C@@H]1[C@H]([C@@H]([C@H](O[C@H]1C2=CC(C([2H])(C3=CC=C(S3)C4=C(C([2H])=C(C([2H])=C4[2H])F)[2H])[2H])=C(C=C2)C)CO)O)O
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– SGLT
Pathway
– Membrane Transporter/Ion Channel
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
