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Cabamiquine (succinate)
$90 – $750
Products Details
Product Description
– Cabamiquine (DDD107498) succinate is a potent and orally active antimalarial agent, inhibits multiple life-cycle stages of the parasite, with an EC50 of 1 nM against P. falciparum 3D7. Cabamiquine succinate inhibits protein synthesis by targeting eEF2/CaMKIII, with an EC50 of 2 nM for WT-PfeEF2[1].
Web ID
– HY-117684A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C31H37FN4O6
References
Р[1]Baraga̱a B, et al. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. J Med Chem. 2016 Nov 10;59(21):9672-9685. |[2]Baraga̱a B, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 2015 Jun 18;522(7556):315-20.
CAS Number
– 2444781-71-7
Molecular Weight
– 580.65
Compound Purity
– 99.99
SMILES
– OC(CCC(O)=O)=O.O=C(C1=CC(C2=CC=C(C=C2)CN3CCOCC3)=NC4=CC=C(C=C41)F)NCCN5CCCC5
Clinical Information
– Phase 2
Research Area
– Infection
Solubility
– DMSO : 135 mg/mL (ultrasonic)
Target
– CaMK;Parasite
Isoform
– CaMK III;Plasmodium
Pathway
– Anti-infection;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
