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Products Details
Product Description
– C105SR is a cyclophilin D (CypD) inhibitor targeting to peptidyl-prolylcis-trans isomerase (PPIase). C105SR inhibits mitochondrial permeability transition opening (mPTP) with an IC 50 of 5 nM. C105SR inhibits hypoxia and reoxygenation inudced hepatocyte apoptosis and increases the level of calcium retention capacity (CRC). C105SR exhibits hepaprotective effect in ischaemia-reperfusion injury (IRI) mouse model[1].
Web ID
– HY-157088
Shipping
– Room temperature
Molecular Formula
– C32H33BrN4O3S
References
– [1]Kheyar A, et al. The novel cyclophilin inhibitor C105SR reduces hepatic ischaemia–reperfusion injury via mitoprotection [J]. JHEP Reports, 2023, 5(11): 100876.
Molecular Weight
– 633.60
SMILES
– O=C([C@@H](NC(NCC1=CC2=C(NCCC2)C=C1)=O)C3=CC(Br)=CC=C3OC)N4[C@@H](C5=C6C(C=CS6)=CC=C5)CCC4
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Caspase
Isoform
– Caspase 3;Caspase 7
Pathway
– Apoptosis
Product type
– Reference compound
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