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Products Details
Product Description
– Antiproliferative against-3 (comp 33) shows a prominent activity against Hela (IC50 = 0.21 µM), A549 (IC50 = 0.39 µM), and MCF-7 (IC50 = 0.33 µM), respectively. Antiproliferative against-3 (comp 33) also dose dependently induces apoptosis by arresting A549 cells at G1 phase[1].
Web ID
– HY-145865
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C39H37FN6O5
References
– [1]Pengqin Chen, et al. Design, synthesis and anticancer evaluation of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 1,8-naphthyridine-3-carboxamide moiety as novel multi-target TKIs. Bioorg Chem. 2022 Apr;121:105672.
Molecular Weight
– 688.75
SMILES
– COC1=C(C=C2N=CC=C(C2=C1)OC3=CC=C(C=C3)NC(C4=CN(C5=C(C4=O)C=CC=N5)C6=CC=C(C=C6)F)=O)OCCCN7CCN(CC7)C
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
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