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Products Details
Product Description
– c-Met-IN-12 (compound 4r) is an orally active, potent and selective type II c-Met kinase inhibitor, with an IC50 of 10.6 nM. c-Met-IN-12 displays high inhibitory effects (inhibition rate > 80% in 1 μM) against AXL, Mer and TYRO3 kinases. c-Met-IN-12 can be used a scaffold for further kinase selectivity enhancement. c-Met-IN-12 shows antitumor efficacy[1].
Web ID
– HY-147695
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C34H29FN4O4
References
– [1]Xu H, et al. Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2. Bioorg Med Chem. 2020 Jun 15;28(12):115555.
CAS Number
– 2426675-70-7
Molecular Weight
– 576.62
SMILES
– CN(C1=CC=NC(NC2=CC(F)=C(C=C2)OC3=C4C=CC(OCC(C)(O)C)=CC4=NC=C3)=C1C5=O)C=C5C6=CC=CC=C6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– c-Met/HGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
