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Products Details
Product Description
– BY27 is a potent and selective BET BD2 inhibitor, shows 38, 5, 7, and 21-fold BD1/BD2 selectivity for BRD2, BRD3, BRD4, and BRDT. Anti-cancer activity[1].
Web ID
– HY-126325
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C22H21ClN6
References
– [1]Chen D, et al. Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins. Eur J Med Chem. 2019 Aug 21;182:111633.
CAS Number
– 2247236-59-3
Molecular Weight
– 404.90
SMILES
– CN1N=CC(C2=CC=C(N3C(CC[C@H]4NC5=CC=C(Cl)C=C5)=NN=C3C)C4=C2)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Epigenetic Reader Domain
Isoform
– BRD2;BRD3;BRD4;BRDT
Pathway
– Epigenetics
Product type
– Reference compound
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