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BX471 (hydrochloride)
$96 – $490
Products Details
Product Description
– BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4.
Web ID
– HY-12080A
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture)
Shipping
– Blue Ice
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H25Cl2FN4O3
Citations
– Cancer Cell. 2021 Mar 8;39(3):423-437.e7.|J Exp Clin Cancer Res. 2022 Mar 3;41(1):81.|Signal Transduct Target Ther. 2021 Feb 28;6(1):91.|Cell Res. 2018 Mar;28(3):323-335. |Immunol Lett. 2018 Oct 12;204:29-37. |J Inflamm Res. 2020 Jul 21;13:343-356.|Lab Invest. 2020 Apr;100(4):619-629.|Research Square Preprint. 2021 Oct.|Sci Adv. 2021 May 26;7(22):eabb5943.|Sci Rep. 2020 Nov 25;10(1):20508.
References
– [1]Horuk R, et al. A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. J Biol Chem. 2001 Feb 9;276(6):4199-204.|[2]Anders HJ, et al. A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation. J Clin Invest. 2002 Jan;109(2):251-9.|[3]Liang M, et al. Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1. J Biol Chem. 2000 Jun 23;275(25):19000-8.|[4]Furuichi K, et al. Chemokine receptor CCR1 regulates inflammatory cell infiltration after renal ischemia-reperfusion injury. J Immunol. 2008 Dec 15;181(12):8670-6.
CAS Number
– 288262-96-4
Molecular Weight
– 471.35
Compound Purity
– 99.51
SMILES
– O=C(N)NC1=CC(Cl)=CC=C1OCC(N2[C@H](C)CN(CC3=CC=C(F)C=C3)CC2)=O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Endocrinology
Solubility
– DMSO : 120 mg/mL (ultrasonic)
Target
– CCR
Isoform
– CCR1
Pathway
– GPCR/G Protein;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
