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BW 755C
SKU
HY-119671-10 mg
Category Reference compound
Tags COX;Lipoxygenase, Endocrinology, Immunology/Inflammation;Metabolic Enzyme/Protease
$160 – $260
Products Details
Product Description
– BW 755C is a 5-lipoxygenase (5-LO) inhibitor with an IC50 of 5 μM. BW 755C also inhibits cyclooxygenase (COX) with IC50s of 0.65 and 1.2 μg/mL against COX-1 and COX-2, respectively[1][2].
Web ID
– HY-119671
Storage Temperature
– -20°C, 3 years (Powder)
Shipping
– Blue Ice
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C10H10F3N3
References
– [1]Hlasta DJ, et al. 5-Lipoxygenase inhibitors: the synthesis and structure-activity relationships of a series of 1-phenyl-3-pyrazolidinones. J Med Chem. 1991 May;34(5):1560-70.|[2]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693-7.|[3]Tanaka N, et al. Comparison of inhibitory actions of indomethacin and epostane on ovulation in rats. Am J Physiol. 1991 Feb;260(2 Pt 1):E170-4.
CAS Number
– 66000-40-6
Molecular Weight
– 229.20
Compound Purity
– 95.0
SMILES
– NC1=NN(C2=CC=CC(C(F)(F)F)=C2)CC1
Clinical Information
– No Development Reported
Research Area
– Endocrinology
Solubility
– 10 mM in DMSO
Target
– COX;Lipoxygenase
Isoform
– 5-LOX;COX-1;COX-2
Pathway
– Immunology/Inflammation;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.