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Products Details
Product Description
– Bupivacaine hydrochloride monohydrate is a NMDA receptor inhibitor. Bupivacaine hydrochloride monohydrate can block sodium, L-calcium, and potassium channels. Bupivacaine hydrochloride monohydrate potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride monohydrate can be used for the research of chronic pain[1][2][3].
Web ID
– HY-W415121
Shipping
– Room temperature
Molecular Formula
– C18H31ClN2O2
References
– [1]Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42.|[2]Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34.|[3]Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na<sup>+</sup> Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468.
CAS Number
– 73360-54-0
Molecular Weight
– 342.90
SMILES
– CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.O.Cl
Clinical Information
– No Development Reported
Research Area
– Cancer, Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Calcium Channel, iGluR, Potassium Channel, Sodium Channel
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel, Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
