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Products Details
Product Description
– Bufrolin is a Cromoglycate (histamine release inhibitor) analog and a high potency agonist of GPR35. Bufrolin promotes interactions between β-arrestin-2 and either human GPR35a or rat GPR35. Bufrolin also serves as antiallergic mast cell stabilizer and inhibit an anti-inflammatory response inducible by the internalization peptide. Bufrolin acts as an anti-inflammatory agent to be used in research of delivering pharmacol linked with internalization peptide[1][2][3].
Web ID
– HY-106481
Shipping
– Room temperature
Molecular Formula
– C18H16N2O6
References
– [1]MacKenzie AE, et al. The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat GPR35. Mol Pharmacol. 2014 Jan;85(1):91-104. |[2]Tymianski M, et al. Co-administration of an agent linked to an internalization peptide with an anti-inflammatory: United States, US8933013 B2. 2015-01-13. |[3]Church M K, et al. Comparison of sodium cromoglycate derivatives, anti-histamines and β-stimulants on histamine release from human lung in vitro[J]. International Archives of Allergy and Immunology, 1981, 66(Suppl. 1): 281-282.
CAS Number
– 54867-56-0
Molecular Weight
– 356.33
SMILES
– O=C1C2=C3C(C(C=C(C(O)=O)N3)=O)=CC(CCCC)=C2NC(C(O)=O)=C1
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– GPR35 ;Histamine Receptor
Pathway
– GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
