Download Files:
Products Details
Product Description
– BTM-3528 is an activator of the mitochondrial protease OMA1 and mediates excessive activation of the mitochondrial integrated stress response (ISR). BTM-3528 stimulates OMA1-dependent DELE1 and OPA1 cleavage and mitochondrial fragmentation. BTM-3528 activates eIF2α kinase HRI, inducing cell growth arrest and apoptosis. BTM-3528 has anticancer activity against multiple DLBCL cell lines and has in vivo inhibitory potency in a mouse model xenografted with human DLBCL SU-DHL-10 cells[1].
Web ID
– HY-149543
Shipping
– Room temperature
Molecular Formula
– C24H19F4N3O2S2
References
– [1]Schwarzer A, et al. Targeting aggressive B-cell lymphomas through pharmacological activation of the mitochondrial protease OMA1. Mol Cancer Ther. 2023 Aug 30.. .
CAS Number
– 2054998-45-5
Molecular Weight
– 521.55
SMILES
– CC(C)SC1=C(C2=CC=C(C(F)(F)F)C=C2)N=C(N3N=C(C)C(C4=CC(F)=CC=C4)=C3C(O)=O)S1
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Eukaryotic Initiation Factor (eIF);Mitochondrial Metabolism
Pathway
– Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
