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Products Details
Product Description
– BTK-IN-9 is a reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. BTK-IN-9 specifically disturbs mitochondrial membrane potential and increases reactive oxygen species level in Z138 cells. BTK-IN-9 also induces cell apoptosis in Z138 cells[1].
Web ID
– HY-115944
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C25H19N7O4
References
– [1]Ran F, et al. Design and synthesis of novel pyrazolopyrimidine-based derivatives as reversible BTK inhibitors with potent antiproliferative activity in mantle cell lymphoma. Med Chem Res, 2022, 31, 594-604.
CAS Number
– 2361192-21-2
Molecular Weight
– 481.46
SMILES
– O=C(NC1=CC=C([N+]([O-])=O)C=C1)CN2N=C(C3=CC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C52
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Btk
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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