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Products Details
Product Description
– BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines[1].
Web ID
– HY-111545
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C24H31N5O4S
References
– [1]Bensinger D, et al. Virtual Screening Identifies Irreversible FMS-like Tyrosine Kinase 3 Inhibitors with Activity toward Resistance-Conferring Mutations. J Med Chem. 2019 Mar 14;62(5):2428-2446.
CAS Number
– 2286419-03-0
Molecular Weight
– 485.60
SMILES
– O=C(C1=C(C)NC(/C=C2C(NC3=C2C=C(NS(=O)(C=C)=O)C=C3)=O)=C1C)NCCN(CC)CC
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FLT3
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
